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Cell - Life Science Journal am 11.02.2021 23:00:00

Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions for optimal therapeutic protection

Zusammenfassung: ... Neutralizing human monoclonal antibodies (mAbs) against SARS-CoV-2 require Fc effector functions for optimal protection during post-exposure therapy, with intact mAbs reducing SARS-CoV-2 burden and lung disease in rodent models better than LALA-PG loss-of-function Fc variant mAbs and requiring monocytes and CD8+ T cells for optimal clinical and virological benefit. ...

Schlagwörter: Associated, COV2-2050, Ontology, Isotype, LALA-PG


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Link zum Artikel bei Cell - Life Science Journal: Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions for optimal therapeutic protection